|
|
TABLE 1
Characteristics of Studies Comparing Corticosteroid Treatment of
Bronchiolitis With a Placebo
|
|
| Study |
Number of
Patients
|
Age Range |
Study Criteria
|
Drug,
Route |
Outcomes Measured§
|
| Treated |
Control |
Inclusion* |
Exclusion |
|
| Dabbous et
al39 |
22 |
22 |
1.5-18
mo |
|
? |
Methylprednisone,
IM |
LOS, CS,
CO2 |
| Springer et
al38 |
25 |
25 |
1.5-11
mo |
|
PW |
Hydrocortisone, IV, then
prednisone, PO |
LOS, CS, PFT |
| Roosevelt et
al35 |
65 |
53 |
1-12 mo |
|
PW, CCD,
ICU |
Dexamethasone, IM |
DOS, CS, DO2, O2
|
| Klassen et al37 |
35 |
32 |
1.5-15 mo |
|
PW,
CCD, SU |
Dexamethasone, PO |
LOS, CS, O2 |
| de Boeck et
al36 |
14 |
15 |
<24 mo |
RSV |
PW, CCD,
PI |
Dexamethasone, IV |
LOS, CS, O2, PFT |
| van Woensel
et al34 |
20 |
19 |
<24
mo |
RSV |
SU |
Prednisolone, PO |
LOS, CS |
|
|
*
RSV indicates only patients with positive RSV laboratory
results included.
|
PW indicates previous wheezing; CCD, chronic cardiorespiratory
disease; ICU, admitted to intensive care unit; SU, recent
corticosteroid use; PI, premature infants.
|
IM indicates intramuscular; IV, intravenous; PO, oral.
|
|
§
CS indicates clinical score; CO2, carbon dioxide
retention; PFT, pulmonary function testing; DO2, duration
of oxygen therapy; O2, oxygen saturation.
|
|