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PEDIATRICS Vol. 102 No. 1 Supplement July 1998, pp. 247-249

COMMENTARY:
Antenatal Detection of Hereditary Disorders, by Henry L. Nadler, MD, Pediatrics, 1968;42:912-918

Received Mar 19, 1998; accepted Mar 19, 1998.

Comments by H. Eugene Hoyme

From the Division of Medical Genetics, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.

Amniotic fluid cells obtained by transabdominal amniocentesis at various stages of pregnancy were cultivated successfully. The intrauterine detection of Down syndrome, galactosemia, and mucopolysaccharidosis was established using the cultivated amniotic fluid cells. The use of this procedure increases the precision of genetic counseling and should stimulate the development of new approaches for the intrauterine management of genetic defects. However, until considerably more experience is gained with these techniques, the procedures should be considered experimental.