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PEDIATRICS Vol. 111 No. 2 February 2003, pp. 321-327

Genome Scan for Childhood and Adolescent Obesity in German Families

Objective. Several genome scans have been performed for adult obesity. Because single formal genetic studies suggest a higher heritability of body weight in adolescence and because genes that influence body weight in adulthood might not be the same as those that are relevant in childhood and adolescence, we performed a whole genome scan.

Methods. The genome scan was based on 89 families with 2 or more obese children (sample 1). The mean age of the index patients was 13.63 ± 2.75 years. A total of 369 individuals were initially genotyped for 437 microsatellite markers. A second sample of 76 families was genotyped using microsatellite markers that localize to regions for which maximum likelihood binomial logarithm of the odd (MLB LOD) scores on use of the concordant sibling pair approach exceeded 0.7 in sample 1.

Results. The regions with MLB LOD scores >0.7 were on chromosomes 1p32.3-p33, 2q37.1-q37.3, 4q21, 8p22, 9p21.3, 10p11.23, 11q11-q13.1, 14q24-ter, and 19p13-q12 in sample 1; MLB LOD scores on chromosomes 8p and 19q exceeded 1.5. In sample 2, MLB LOD scores of 0.68 and 0.71 were observed for chromosomes 10p11.23 and 11q13, respectively.

Conclusion. We consider that several of the peaks identified in other scans also gave a signal in this scan as promising for ongoing pursuits to identify relevant genes. The genetic basis of childhood and adolescent obesity might not differ that much from adult obesity.

Kathrin Saar, PhD*,{ddagger}, Frank Geller, MSC§, Franz Rüschendorf, PhD*, André Reis, Prof*,||, Susann Friedel, MSC, Nadine Schäuble, MSC, Peter Nürnberg, PhD*, Wolfgang Siegfried, MD#, Hans-Peter Goldschmidt, MD**, Helmut Schäfer, Prof§, Andreas Ziegler, Prof{ddagger}{ddagger}, Helmut Remschmidt, Prof||, Anke Hinney, PhD|| and Johannes Hebebrand, Prof||

* Molecular Genetics and Gene Mapping Center, Max Delbrück Center, Berlin, Germany
{ddagger} Max Planck Institute for Molecular Genetics, Berlin, Germany
§ Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany
|| Institute of Human Genetics, University of Erlangen, Erlangen, Germany
Clinical Research Group, Department of Child and Adolescent Psychiatry of the Philipps-University Marburg, Marburg, Germany
# Obesity Treatment Center Insula, Berchtesgaden, Germany
** Spessartklinik, Bad Orb, Germany
{ddagger}{ddagger} Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

Key Words: linkage analysis • BMI • body weight

Abbreviations: BMI, body mass index • ECSP, extremely concordant sibling pair • MLB LOD, maximum likelihood binomial logarithm of the odd • PCR, polymerase chain reaction

Received for publication Mar 26, 2002; Accepted Aug 15, 2002.




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