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PEDIATRICS Vol. 111 No. 2 February 2003, pp. 332-338

Physical Fitness and C-Reactive Protein Level in Children and Young Adults: The Columbia University BioMarkers Study

Objective. To examine the association of physical fitness with C-reactive protein (CRP) level in children and young adults.

Methods. Subjects (N = 205) aged 6 to 24 years were enrolled in the Columbia University BioMarkers Study (1994–1998). Physical fitness was assessed using a non-effort-dependent treadmill testing protocol (physical work capacity at heart rate of 170 beats per minute). CRP level was measured using a high-sensitivity assay.

Results. Subjects were 54% female and 65% of Hispanic origin. Mean fitness level was higher in boys than in girls, but CRP levels did not differ by gender. Fitness level was inversely correlated with CRP (r = –0.22). This relationship was significant in boys (r = –0.32) but not in girls (r = –0.15). After multivariate regression adjustment for age, race/ethnicity, body mass index, and family history of early-onset ischemic heart disease, physical fitness remained inversely associated with CRP level in boys (ß = –0.02; standard error = 0.01).

Conclusions. These findings indicate that physical fitness is inversely related to CRP level in children and that this relationship is more pronounced in boys than in girls.

Carmen R. Isasi, MD, PhD*,{ddagger}, Richard J. Deckelbaum, MD§, Russell P. Tracy, PhD||, Thomas J. Starc, MD, Lars Berglund, MD, PhD# and Steven Shea, MD, MS*,{ddagger}

* Division of General Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
{ddagger} Department of Epidemiology, Joseph Mailman School of Public Health, Columbia University, New York, New York
§ Institute of Human Nutrition and Department of Pediatrics, Columbia University, New York, New York
|| Departments of Pathology and Biochemistry, University of Vermont, Colchester, Vermont
Division of Pediatric Cardiology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York
# Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, Department of Medicine, University of California Davis, Sacramento, California

Key Words: children • C-reactive protein • fitness • obesity • physical fitness

Abbreviations: CRP, C-reactive protein • IL-6, interleukin-6 • PWC170, physical work capacity at heart rate of 170 beats per minute • BMI, body mass index • SE, standard error

Received for publication Feb 19, 2002; Accepted Aug 14, 2002.




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