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Non-Group A or B Streptococcal and...

PEDIATRICS Vol. 111 No. 3 March 2003, pp. 541-547

Early-Onset Group B Streptococcal Infection After a Combined Maternal and Neonatal Group B Streptococcal Chemoprophylaxis Strategy

Sithembiso Velaphi, MB*, Jane D. Siegel, MD*, George D. Wendel, Jr, MD{ddagger}, Nancy Cushion, MBA, RN*, Walid M. Eid, MD* and Pablo J. Sánchez, MD*

* Departments of Pediatrics
{ddagger} Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas

--> Objective. In January 1995, a combined maternal and neonatal protocol for prevention of early-onset group B streptococcal (GBS) infection was implemented that consisted of a risk factor-based approach for maternal intrapartum chemoprophylaxis using ampicillin combined with a single intramuscular dose of penicillin given to all newborns within 1 hour of delivery. The objective of this study was to review the cases of early-onset GBS infections that occurred from 1995 to 1999 to identify factors associated with their continued occurrence despite implementation of a GBS chemoprophylaxis protocol.

Methods. Infants <=72 hours of age with early-onset GBS infection born at Parkland Memorial Hospital in Dallas from January 1995 to December 1999 were identified through a prospective laboratory-based surveillance system. Maternal and infant medical records were reviewed for clinical and demographic data.

Results. There were 32 cases (0.47/1000 live births) of early-onset GBS infection for the 5-year period. This represented a 76% reduction compared with the rate from 1986 to 1994 (1.95/1000), when there was no protocol for GBS chemoprophylaxis. Thirteen cases (41%) did not have any identifiable maternal risk factor. Of the 19 cases (59%) with risk factors, maternal intrapartum fever was the most frequent (15 [79%]), followed by prematurity (6 [32%]) and prolonged rupture of membranes (6 [32%]). Among the 19 mothers with risk factors, 15 (79%) mothers received intrapartum chemoprophylaxis, and 12 (80%) of the 15 mothers had intrapartum fever. Only 33% of mothers with risk factors received >=2 doses of intrapartum chemoprophylaxis, and among those with intrapartum fever, 25% received >=2 doses. None of the 32 infants with early-onset GBS infection received the combination of intrapartum ampicillin and postnatal penicillin.

Conclusions. A combined obstetric and neonatal chemoprophylaxis protocol significantly reduced early-onset GBS infection. Maternal intrapartum fever was the most frequent risk factor associated with failure of chemoprophylaxis.

Key Words: group B streptococcus • chemoprophylaxis • penicillin G • neonatal sepsis • ampicillin

Abbreviations: GBS, group B streptococcus • PMH, Parkland Memorial Hospital • IM, intramuscular • CSF, cerebrospinal fluid • IV, intravenous • PROM, prolonged rupture of membranes • CDC, Centers for Disease Control and Prevention

Received for publication Jun 12, 2002; Accepted Sep 26, 2002.




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