This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rivkees, S. A.
Right arrow Articles by Cornelius, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rivkees, S. A.
Right arrow Articles by Cornelius, E. A.
Related Collections
Right arrow Endocrinology

PEDIATRICS Vol. 111 No. 4 April 2003, pp. 745-749

Influence of Iodine-131 Dose on the Outcome of Hyperthyroidism in Children

Scott A. Rivkees, MD and Eugene A. Cornelius, MD, PhD

From the Departments of Pediatrics and Diagnostic Imaging, Yale University School of Medicine, New Haven, Connecticut

--> Objectives. Iodine-131 is an effective treatment for Graves’ hyperthyroidism in children and adults. Yet the responses to treatment as related to iodine-131 dose in children are not well-defined. The objective of this study was to examine the relationship between the dose of iodine-131 in children with hyperthyroidism and thyroid status 1 year after treatment.

Methods. We examined the outcome of iodine-131 treatment in children and adolescents with Graves’ disease, as related to dose. Three iodine-131 doses were compared: 72 to 108 Gy (80–120 µCi/g), 180 to 225 Gy (200–250 µCi/g), and 270 to 364 Gy (300–405 µCi/g) in 31 patients ranging in age from 7 to 18 years old. Thyroid status was assessed >1 year after therapy.

Results. We found that doses of 100 Gy (110 µCi/g), 200 Gy (220 µCi/g), and 300 Gy (330 µCi/g) resulted in hypothyroidism in 50%, 70%, and 95% of treated individuals, respectively. These data show that to insure ablation of thyroid tissue doses, >270 Gy (300 µCi/g) is needed, especially when the thyroid is large.

Key Words: thyroid • hyperthyroidism • Graves’ disease • radioactive iodine

Abbreviations: CTTFS, Cooperative Thyrotoxicosis Therapy Follow-up Study • rem, roentgen-equivalent-man

Received for publication Apr 15, 2002; Accepted Sep 11, 2002.




This article has been cited by other articles:


Home page
 PediatricsHome page
N. S. Glaser, D. M. Styne, and for the Organization of Pediatric Endocrinologists
Predicting the Likelihood of Remission in Children With Graves' Disease: A Prospective, Multicenter Study
Pediatrics, March 1, 2008; 121(3): e481 - e488.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. Rivkees and C. Dinauer
An Optimal Treatment for Pediatric Graves' Disease Is Radioiodine
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 797 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
P Dharmaraj and A Grueters
The management of thyrotoxicosis in a pre-pubertal child with 18p deletion syndrome
Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S145 - S147.
[Abstract] [Full Text] [PDF]

Home page
 Pediatr. Rev.Home page
F. Kokotos and H. M. Adam
Hyperthyroidism
Pediatr. Rev., April 1, 2006; 27(4): 155 - 157.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Rivkees
Radioactive Iodine Use in Childhood Graves' Disease: Time to Wake Up and Smell the I-131
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4227 - 4228.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. H. Read Jr., M. J. Tansey, and Y. Menda
A 36-Year Retrospective Analysis of the Efficacy and Safety of Radioactive Iodine in Treating Young Graves' Patients
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4229 - 4233.
[Abstract] [Full Text] [PDF]